\(\left(2+1\right)\left(2^2+1\right)\left(2^4+1\right)\left(2^8+1\right)\)
\(=\left(2-1\right)\left(2+1\right)\left(2^2+1\right)\left(2^4+1\right)\left(2^8+1\right)\)
\(=\left(2^2-1\right)\left(2^2+1\right)\left(2^4+1\right)\left(2^8+1\right)\)
\(=\left(2^4-1\right)\left(2^4+1\right)\left(2^8+1\right)\)
\(=\left(2^8-1\right)\left(2^8+1\right)\)
\(=2^{64}-1\)