\(\left(x^2+4\right)\left(x^2-16\right)< 0\)
\(\Rightarrow\hept{\begin{cases}x^2+4>0;x^2-16< 0\\x^2+4< 0;x^2-16>0\end{cases}}\)
\(\Rightarrow\hept{\begin{cases}x^2>-4;x^2< 16\\x^2< -4;x^2>16\end{cases}}\)
\(\Rightarrow-4< x^2< 16\)
\(\Rightarrow x\in\left\{1;4;9\right\}.\)