\(\left(x^2-9\right)^2-\left(x+3\right)\left(x-3\right)\left(x^2+9\right)=\left(x-3\right)^2\left(x+3\right)^2-\left(x+3\right)\left(x-3\right)\left(x^2+9\right)\)
\(=\left(x-3\right)\left(x+3\right)\left[\left(x-3\right)\left(x+3\right)-x^2+9\right]=\left(x-3\right)\left(x+3\right)\left[x^2-9-x^2-9\right]=\left(x-3\right)\left(x+3\right)\cdot\left(-18\right)\)
\(=-18\left(x+3\right)\left(x-3\right)\)