\(4\left(x^2+15x+50\right)\left(x^2+18x+72\right)-3x^2\)
\(=4\left(x+5\right)\left(x+10\right)\left(x+12\right)\left(x+6\right)-3x^2\)
\(=4\left(x^2+17x+60\right)\left(x^2+16x+60\right)-3x^2\)
\(=4\left(x+60\right)^2+132x\left(x+60\right)+1088x^2-3x^2\)
\(=4\left(x+60\right)^2+132x\left(x+60\right)+1085x^2\)
\(=4\left(x+60\right)^2+62x\left(x+60\right)+70x\left(x+60\right)+1085x^2\)
\(=2\left(x+60\right)\left[2\left(x+60\right)+31x\right]+35x\left[2\left(x+60\right)+31x\right]\)
\(=\left(33x+120\right)\left(2x+120+35x\right)\)
\(=3\left(11x+40\right)\left(37x+120\right)\)