\(\frac{5^2.6^9.10+6^5.2^3.15^3}{5^2.6^8.10-2.6^8.10^3}=\frac{5^2.2^9.3^9.2.5+2^5.3^5.2^3.5^3.3^3}{5^2.2^8.3^8.2.5-2.2^8.3^8.2^3.5^3}\)
\(=\frac{2^{10}.3^9.5^3+2^8.3^8.5^3}{2^9.3^8.5^3-2^{12}.3^8.5^3}=\frac{2^8.3^8.5^3\left(2^2.3+1\right)}{2^9.3^8.5^3\left(1-2^3\right)}\)
\(=\frac{13}{2.-7}=-\frac{13}{14}\)