\(2xy-x^2-y^2+16\)
\(=-\left(x^2-2xy+y^2-16\right)\)
\(=-\left[\left(x^2-2xy+y^2\right)-4^2\right]\)
\(=-\left[\left(x-y\right)^2-4^2\right]\)
\(=-\left[\left(x-y-4\right)\left(x-y+4\right)\right]\)
\(=-\left(x-y-4\right)\left(x-y+4\right)\)
\(=16-\left(x^2-2xy+y^2\right)\)
\(=4^2-\left(x-y\right)^2\)
\(=\left(4-x+y\right)\left(4+x-y\right)\)