\(\left(x+4\right)^2-81=0\Leftrightarrow\left(x+4\right)^2-9^2=0\)
\(\Leftrightarrow\left(x+4+9\right)\times\left(x+4-9\right)=0\)
\(\Leftrightarrow\left(x+13\right)\times\left(x-5\right)=0\)
\(\left[{}\begin{matrix}x+13=0\\x-5=0\end{matrix}\right.\Leftrightarrow\left[{}\begin{matrix}x=-13\\x=5\end{matrix}\right.\)