\(F=-x^4+x^2-4y^2+2x-4y+2000.\)
\(=-x^4+2x^2-1-x^2+2x-1-4y^2-4y-1+2003\)
\(=-\left(x^2-1\right)^2-\left(x-1\right)^2-\left(2y+1\right)^2+2003\)
\(=-\left(x-1\right)^2\left(x+1\right)^2-\left(x-1\right)^2-\left(2y+1\right)^2+2003\)
\(\Rightarrow F_{min}=2003\Leftrightarrow\hept{\begin{cases}\left(x-1\right)^2=0\\\left(2y+1\right)^2=0\end{cases}\Rightarrow\hept{\begin{cases}x=1\\y=-\frac{1}{2}\end{cases}}}\)
Vậy \(F_{min}=2003\Leftrightarrow x=1;y=-\frac{1}{2}\)