Lời giải:
ĐKXĐ: $x\neq \pm 2; x\neq -3$
Ta có:
$M=1+\frac{x+3}{(x+2)(x+3)}:\left(\frac{8x}{4x^2(x-2)}-\frac{3x}{3(x-2)(x+2)}-\frac{1}{x+2}\right)$
$=1+\frac{1}{x+2}:\left(\frac{2}{x(x-2)}-\frac{x}{(x-2)(x+2)}-\frac{1}{x+2}\right)$
$=1+\frac{1}{x+2}:\frac{2(x+2)-x^2-x(x-2)}{x(x-2)(x+2)}$
$=1+\frac{1}{x+2}:\frac{-2(x^2-2x-2)}{x(x-2)(x+2)}$
$=1-\frac{x(x-2)}{2x^2-4x-4}=\frac{x^2-2x-4}{2x^2-4x-4}$