Ta có: \(\left\{{}\begin{matrix}y^4+1\ge2y^2\\16x^4+1\ge8x^2\end{matrix}\right.\) \(\Rightarrow\left(y^4+1\right)\left(16x^4+1\right)\ge16x^2y^2\)
Dấu "=" xảy ra khi và chỉ khi: \(\left\{{}\begin{matrix}y^4=1\\16x^4=1\end{matrix}\right.\) \(\Rightarrow\left\{{}\begin{matrix}y=\pm1\\x=\pm\frac{1}{2}\end{matrix}\right.\)