\(M=\left(-x-8\right)-\left(-3x+10\right)-\left(x-10\right)\\ =-x-8+3x-10-x+10\\ =\left(-x+3x-x\right)+\left(-8-10+10\right)\\ =x-8\)
\(N=-\left(x-100\right)+\left(-3x+10\right)-\left(-x-100\right)\\ =-x+100+-3x+10+x+100\\ =\left(-x+-3x+x\right)+\left(100+10+100\right)\\ =-3x+210\\ =3\left(-x+70\right)\)
\(Q=100-\left(-4x+1\right)-\left(99+x\right)-\left(x-1\right)\\ =100+4x-1-99-x-x+1\\ =\left(4x-x-x\right)+\left(100-1-99+1\right)\\ =2x+1\)