\(a,4x^4-21x^2y^2+y^4=\left(2x^2\right)^2+4x^2y^2+y^4-4x^2y^2-21x^2y^2\)
\(=\left(2x^2+y^2\right)^2-25x^2y^2\)
\(=\left(2x^2+y^2-5xy\right)\left(2x^2+y^2+5xy\right)\)
\(b,x^5-5x^3+4x=x\left(x^4-5x^2+4\right)\)
\(=x\left(x^4-4x^2-x^2+4\right)\)
\(=x\left[x^2\left(x^2-4\right)-\left(x^2-4\right)\right]\)
\(=x\left(x^2-4\right)\left(x^2-1\right)\)
\(=x\left(x-2\right)\left(x+2\right)\left(x-1\right)\left(x+1\right)\)
\(c,x^3+5x^2+3x-9=x^3-x^2+6x^2-6x+9x-9\)
\(=x^2\left(x-1\right)+6x\left(x-1\right)+9\left(x-1\right)\)
\(=\left(x-1\right)\left(x^2+6x+9\right)\)
\(=\left(x-1\right)\left(x^2+3x+3x+9\right)\)
\(=\left(x-1\right)\left[x\left(x+3\right)+3\left(x+3\right)\right]\)
\(=\left(x-1\right)\left(x+3\right)\left(x+3\right)\)
\(=\left(x-1\right)\left(x+3\right)^2\)
\(d,x^{16}+x^8-2=x^{16}+2x^8-x^8-2\)
\(=x^8\left(x^8-1\right)+2\left(x^8-1\right)\)
\(=\left(x^8-1\right)\left(x^8+2\right)\)