\(100:\left\{250:\left[450-\left(4\cdot5^3-2^2\cdot25\right)\right]\right\}\)
\(=100:\left\{250:\left[450-\left(4\cdot125-4\cdot25\right)\right]\right\}\)
\(=100:\left\{250:\left[450-\left(500-100\right)\right]\right\}\)
\(=100:\left[250:\left(450-400\right)\right]\)
\(=100:\left(250:50\right)\)
\(=100:5\)
\(=20\)