\(3\left(2^2+1\right)\left(2^4+1\right)\left(2^8+1\right)\left(2^{16}+1\right)\\=\left(2^2-1\right)\left(2^2+1\right)\left(2^4+1\right)\left(2^8+1\right)\\ =\left(2^4-1\right)\left(2^4+1\right)\left(2^8+1\right)\left(2^{16}+1\right)\\ =\left(2^8-1\right)\left(2^8+1\right)\left(2^{16}+1\right)\\ =\left(2^{16}-1\right)\left(2^{16}+1\right)\\ =2^{32}-1 \)