\(4x^4+81=\left(2x\right)^2+2.2x^2.9+9^2-36x^2\)
\(=\left(2x^2+9\right)^2-\left(6x\right)^2=\left(2x^2-6x+9\right)\left(2x^2+6x+9\right)\)
\(64x^4+y^4=\left(8x^2\right)^2+2.8x^2.y^2+\left(y^2\right)^2-16x^2y^2\)
\(=\left(8x^2+y^2\right)^2-\left(4xy\right)^2=\left(8x^2-4xy+y^2\right)\left(8x^2+4xy+y^2\right)\)