\(\frac{x^2+y^2}{xy}=\frac{10}{3}\Rightarrow3x^2+3y^2-10xy=0\)
\(\Rightarrow\left(3x^2-9xy\right)-\left(xy-3y^2\right)=0\Rightarrow3x\left(x-3y\right)-y\left(x-3y\right)=0\)
\(\Rightarrow\left(x-3y\right)\left(3x-y\right)=0\Rightarrow3x-y=0\left(y>x>0\Rightarrow x-3y< 0\right)\Rightarrow3x=y\)
\(M=\frac{x-y}{x+y}=\frac{x-3x}{x+3x}=\frac{-2x}{4x}=-\frac{1}{2}\)