\(\left(x+2\right)\left(x-2\right)-\left(x-3\right)\left(x+1\right)\)
\(=x^2-4-\left(x^2-2x-3\right)\)
\(=2x-1\)
\(\left(2^2-1\right)\left(2^2+1\right)\left(2^4+1\right)\left(2^8+1\right)\left(2^{16}+1\right)\)
\(=\left(2^4-1\right)\left(2^4+1\right)\left(2^8+1\right)\left(2^{16}+1\right)\)
\(=\left(2^8-1\right)\left(2^8+1\right)\left(2^{16}+1\right)\)
\(=\left(2^{16}-1\right)\left(2^{16}+1\right)\)
\(=2^{32}-1\)