.______ careful preparation, they had a lot of difficulties in making the film. 

A. Despite of

B. Although

C. In spite of

Although Sue felt tired, she stayed up late talking to Jill. 

A. Despite feeling tired, Sue stayed up late talking to Jill.

B. In spite feeling tired, Sue stayed up late talking to Jill.

C. Sue wouldn’t feel tired despite staying up late talking to Jill.

D. Sue stayed up late talking to Jill. As a result, she was tired.